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To prepare for a colonoscopy, you will need a gallon jug of Nu-Lytely, which can be obtained from your pharmacy. The day before the procedure, you must follow a clear liquid diet. In the morning, dilute the Nu-Lytely with a gallon of water and refrigerate it. Between 6 and 7 PM on the day before the procedure, start drinking eight ounces of the solution every 15 to 20 minutes until you have consumed half the gallon. If you experience discomfort or bloating, you can pause or lengthen the time between each glass. Six hours before the procedure, begin drinking the remaining half of the solution in the same manner. Expect diarrhea for several hours after finishing the solution, so it’s important to be near a restroom.